Payment & Shipping Terms:
|Category:||Drug Abuse TESGTING Kits||Format:||STRIP MPD 3mm|
|Specimen:||Urine||Testing Time:||5 Minu|
|Shelf Life:||24 Months||Application:||MPD Drug Test Strip|
Drug Abuse Test Kit MPD Rapid Test 3mm strip ,high sensitivity cut-off 1000ng/ml
MPD ( ritalinic acid) Rapid Diagnostic Test
Methylphenidate (tradenames Concerta, Methylin, Medikinet, Ritalin, Equasym XL, Quillivant XR, Metadate) is acentral nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD), postural orthostatic tachycardia syndrome and narcolepsy. Methylphenidate has been studied and researched for over 50 years and has a very good efficacy and safety record for the treatment of ADHD. It was first licensed by the U.S. Food and Drug Administration (FDA) in 1955 for treating what was then known as hyperactivity. Prescribed to patients beginning in 1960, the drug has become increasingly heavily prescribed since the 1990s, when the diagnosis of ADHD itself became more widely accepted.  ADHD and other similar conditions are believed to be linked to sub-performance of the dopamine and norepinephrine functions in the brain, primarily in the prefrontal cortex, responsible for self-regulatory function (e.g., inhibition, motivation, and memory) and executive function (e.g., reasoning, organizing, problem solving, and planning).Methylphenidate's mechanism of action involves the inhibition of catecholamine reuptake, primarily as a dopamine reuptake inhibitor. Methylphenidate acts by blocking the dopamine transporter and norepinephrine transporter, leading to increased concentrations of dopamine and norepinephrine within the synaptic cleft. This effect in turn leads to increased neurotransmission of dopamine and norepinephrine. Methylphenidate is also a 5HT1A receptor agonist.
Methylphenidate taken orally has a bioavailability of 11-52% with duration of action around 1-4 hours for instant release, 3–8 hours for sustained release, and 8–12 hours for extended release (Concerta) . The major metabolite of methylphenidate is ritalinic acid and methylphenidate; the metabolite of 80% had excreted by urine within 24 hours, the concentration of ritalinic acid min after administration was eight times higher than that of methylphenidate .
The MPD Rapid Test Panel (Urine) is a rapid urine-screening test that can be performed without the use of an instrument. The test utilizes the antibody to selectively detect elevated levels of ritalinic acid in urine. The MPD Rapid Test Panel (Urine) yields a positive result when the ritalinic acid in urine exceeds the cut-off level.
The FYL Rapid Test Cassette (Urine) is an immunoassay based on the principle of competitive binding. Drugs which may be present in the urine specimen compete against the drug conjugate for binding sites on the antibody.
During testing, a urine specimen migrates upward by capillary action. Fentanyl, if present in the urine specimen below 20 ng/mL, will not saturate the binding sites of antibody-coated particles in the test device. The antibody-coated particles will then be captured by immobilized FYL conjugate and a visible colored line will show up in the test line region. The colored line will not form in the test line region if the FYL level exceeds 20 ng/mL because it will saturate all the binding sites of anti-FYL antibodies.
A drug-positive urine specimen will not generate a colored line in the test line region, while a drug-negative urine specimen or a specimen containing a drug concentration less than the cut-off will generate a line in the test line region. To serve as a procedural control, a colored line will always appear at the control line region indicating that proper volume of specimen has been added and membrane wicking has occurred.
SPECIMEN COLLECTION AND STORAGE
The urine specimen must be collected in a clean and dry container. Urine collected at any time of the day may be used. Urine specimens exhibiting visible particles should be centrifuged, filtered, or allowed to settle to obtain clear specimen for testing. Specimen.
Urine specimens may be stored at 2-8°C for up to 48 hours prior to testing. For long-term storage, specimens may be frozen and stored below -20°C. Frozen specimens should be thawed and mixed before testing.
Store as packaged in the sealed pouch either at room temperature or refrigerated (2-30°C). The test is stable through the expiration date printed on the sealed pouch. The test must remain in the sealed pouch until use. DO NOT FREEZE. Do not use beyond the expiration date.
1. The 6-MAM Rapid Test Cassette provides only a qualitative, preliminary analytical result. A secondary analytical method must be used to obtain a confirmed result. Gas chromatography/mass spectrophotometry (GC/MS) is the preferred confirmatory method2.3.
2. It is possible that technical or procedural errors, as well as other interfering substances in the urine specimen may cause erroneous results.
3. Adulterants, such as bleach and/or alum, in urine specimens may produce erroneous results regardless of the analytical method used. If adulteration is suspected, the test should be repeated with another urine specimen.
4. A positive result indicates presence of the drug or its metabolites but does not indicate level of intoxication, administration route or concentration in urine.
5. A negative result may not necessarily indicate drug-free urine. Negative results can be obtained when drug is present but below the cut-off level of the test.
A side-by-side comparison was conducted using the Rapid Test Cassette (Urine) and GC/MS. The following results were tabulated:
|Ritalinic Acid||Percent of Cut-off||n||Visual Result|
|ORIENT NEW LIFE MEDICAL CO., LTD.|
|Email:||Jerry @ newlifebiotest .com|
Contact Person: Jerry Meng