Anti-MPD Mouse Monoclonal Antibody Anti-Methylphenidate

Introduction:

Methylphenidate (tradenames Concerta, Methylin, Medikinet, Ritalin, Equasym XL, Quillivant XR, Metadate) is acentral nervous system(CNS) stimulant of the phenethylamine[1] and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD),postural orthostatic tachycardia syndrome and narcolepsy. Methylphenidate has been studied and researched for over 50 years and has a very good efficacy and safety record for the treatment of ADHD.[2] It was first licensed by the U.S. Food and Drug Administration (FDA) in 1955 for treating what was then known as hyperactivity. Prescribed to patients beginning in 1960, the drug has become increasingly heavily prescribed since the 1990s, when the diagnosis of ADHD itself became more widely accepted. [3] ADHD and other similar conditions are believed to be linked to sub-performance of the dopamine and norepinephrine functions in the brain, primarily in the prefrontal cortex, responsible for selfregulatory function (e.g., inhibition, motivation, and memory) and executive function (e.g., reasoning, organizing, problem solving, and planning).[4][5]Methylphenidate's mechanism of action involves the inhibition of catecholamine reuptake, primarily as a dopamine reuptake inhibitor. Methylphenidate acts by blocking the dopamine transporter and norepinephrine transporter, leading to increased concentrations of dopamine and norepinephrine within the synaptic cleft. This effect in turn leads to increased neurotransmission of dopamine and norepinephrine. Methylphenidate is also a 5HT1A receptor agonist.[6] Methylphenidate taken orally has a bioavailability of 11-52% with duration of action around 1-4 hours for instant release, 3–8 hours for sustained release, and 8–12hours for extended release (Concerta) [7]. The major metabolite of methylphenidate is ritalinic acid and methylphenidate; the metabolite of 80% had excreted by urine within 24 hours, the concentration of ritalinic acid min after administration was eight times higher than that of methylphenidate

Specification Data

Accidental Release Measures

Personal Precautions: Take proper precautions to minimize exposure by using appropriate personal protective equipment. Shut off all sources of ignition.

Environmental Precautions: No special measures required.

FAQ

1. Q:Are you a factory or trading company?
A: We are a factory, we have rich experience for manufacturing Medical Device more than 10 years.
2.Q:Where is your factory located? How can i visit there?
A: Our factory is located in Jiaxing city, Zhejiang Province, China.
It is about more than 1 hours from Shanghai.

2. 3.Q:Can you make samples?
A: Yes, we can make samples for you.
4.Q:How does your factory do as quality control?
A: Quality is the lift of our factory. We have inspector in different post, and there are three inspectors before packing to get best quality products.
5.Q: How is your post market service ?
A: If any damaged rings in the course of carriage, with the checking it's our mistake, we will take full responsibility to compensate the customers.

6.Q:Can you do OEM for us?
A: Certainly. We also can build the moulding for our new customer.

7.Q:Does the price include freight?
A:No, please choose the express service provider or negotiate with us.